{"id":13810,"date":"2025-04-30T17:16:33","date_gmt":"2025-04-30T09:16:33","guid":{"rendered":"https:\/\/ruidapacking.com\/?p=13810"},"modified":"2026-09-01T19:42:39","modified_gmt":"2026-09-01T11:42:39","slug":"what-are-enteric-coated-tablets","status":"publish","type":"post","link":"https:\/\/ruidapacking.com\/fr\/what-are-enteric-coated-tablets\/","title":{"rendered":"Que sont les comprim\u00e9s gastro-r\u00e9sistants\u00a0? Avantages, utilisations et guide du mat\u00e9riel pharmaceutique<\/span>"},"content":{"rendered":"\n

1. Introduction<\/h2>\n\n\n\n

Enteric coated tablets have become a staple in modern pharmaceutical formulations, especially for medications that must bypass the acidic environment of the stomach. In order to produce enteric coating tablets, the pharmaceutical equipment, particularly tablet coating machines, play a crucial role. In this guide, we\u2019ll explore what enteric coated tablets are, how they work, the types of coating methods in pharmaceutical industry, and what machinery is needed to produce them.<\/p>\n\n\n\n

\"different<\/figure>\n\n\n\n

<\/p>\n\n\n\n

2. Qu\u2019est-ce que l\u2019enrobage ent\u00e9rique ?<\/h2>\n\n\n\n

Enteric coating is a protective layer applied to tablets, capsules, or caplets that prevents them from dissolving in the acidic environment of the stomach. Instead, this coating ensures that the medication passes through the stomach intact and only dissolves in the more neutral or alkaline environment of the intestines.<\/p>\n\n\n\n

Enteric coating is commonly made from pH-sensitive polymers that remain stable in low pH (acidic) but break down at higher pH levels (typically above pH 5.5 to 7.0), which are found in the small intestine. Enteric coatings are especially useful for:<\/p>\n\n\n\n

\u2022 Protecting acid-sensitive active ingredients<\/p>\n\n\n\n

\u2022 Preventing stomach irritation caused by certain medications<\/p>\n\n\n\n

\u2022 Targeting drug release to the intestines for better absorption or therapeutic effect<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n\n\n\n

3. Comment fonctionnent les comprim\u00e9s \u00e0 enrobage ent\u00e9rique\u00a0?<\/h2>\n\n\n\n

Enteric coated tablets work by using a specialized outer layer that resists the acidic pH of the stomach but dissolves in the more neutral or alkaline pH of the intestines. Here’s how the process works step-by-step:<\/p>\n\n\n\n

    \n
  • Ingestion: <\/strong>Une fois le comprim\u00e9 aval\u00e9, il traverse l\u2019\u0153sophage jusqu\u2019\u00e0 l\u2019estomac.<\/li>\n\n\n\n
  • R\u00e9sistance aux acides : <\/strong>L\u2019enrobage ent\u00e9rique reste intact dans l\u2019estomac (pH 1,0\u20133,5), prot\u00e9geant les ingr\u00e9dients actifs contre la lib\u00e9ration ou la d\u00e9gradation par l\u2019acide gastrique.<\/li>\n\n\n\n
  • Transit vers les intestins : <\/strong>Le comprim\u00e9 p\u00e9n\u00e8tre dans l\u2019intestin gr\u00eale, o\u00f9 le pH augmente progressivement jusqu\u2019\u00e0 environ 6,5\u20137,5.<\/li>\n\n\n\n
  • Dissolution du rev\u00eatement : <\/strong>L'enrobage ent\u00e9rique est con\u00e7u pour se dissoudre \u00e0 ce pH plus \u00e9lev\u00e9, permettant au comprim\u00e9 de se briser et de lib\u00e9rer son ingr\u00e9dient pharmaceutique actif (API).<\/li>\n\n\n\n
  • Absorption cibl\u00e9e : <\/strong>Le m\u00e9dicament est ensuite absorb\u00e9 dans l'intestin, soit pour un traitement localis\u00e9 (par exemple, des anti-inflammatoires pour les affections intestinales), soit pour une circulation syst\u00e9mique.<\/li>\n<\/ul>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    <\/p>\n\n\n\n

    (Cr\u00e9dit photo : https:\/\/www.pharmapproach.com\/enteric-coating-2\/)<\/p>\n\n\n\n

    4. Exemples de m\u00e9dicaments \u00e0 enrobage ent\u00e9rique<\/h2>\n\n\n\n

    Enteric coated tablets are widely used in both prescription and over-the-counter (OTC) medications. In the pharmaceutical and nutraceutical industries, enteric coating is applied to a variety of dosage forms, including enteric-coated tablets and enteric coated caplets. Each form offers different benefits depending on formulation goals, drug type, and manufacturing preferences.<\/p>\n\n\n\n

    Enrobage ent\u00e9rique commun <\/b><\/strong>Drogues<\/b><\/strong><\/p>\n\n\n\n

    Here below are some enteric coated tablets examples for the commonly used enteric coated drugs for different category and different reasons.<\/p>\n\n\n\n

    \n

    Pilules pour<\/b><\/strong><\/p>\n<\/td>

    		\n

    Cat\u00e9gorie<\/b><\/strong><\/p>\n<\/td>

    		\n

    Pourquoi utiliser un enrobage ent\u00e9rique<\/b><\/strong><\/p>\n<\/td><\/tr>

    \n

    Acide gastrique<\/p>\n<\/td>

    		\n

    inhibiteur de la pompe \u00e0 protons<\/p>\n<\/td>

    		\n

    Prot\u00e8ge les m\u00e9dicaments sensibles \u00e0 l'acide\u00a0; am\u00e9liore l'absorption dans les intestins<\/p>\n<\/td><\/tr>

    \n

    Gastrique<\/p>\n<\/td>

    		\n

    Anti-inflammatoire\/AINS<\/p>\n<\/td>

    		\n

    R\u00e9duit l'irritation gastrique ; utilis\u00e9 pour la sant\u00e9 cardiaque<\/p>\n<\/td><\/tr>

    \n

    analg\u00e9sique<\/p>\n<\/td>

    		\n

    Soulagement de la douleur\/AINS<\/p>\n<\/td>

    		\n

    Retarde la lib\u00e9ration pour pr\u00e9venir les ulc\u00e8res gastriques<\/p>\n<\/td><\/tr>

    \n

    Probiotiques<\/p>\n<\/td>

    		\n

    Compl\u00e9ment pour la sant\u00e9 intestinale<\/p>\n<\/td>

    		\n

    Enteric coated probiotics protect live cultures through stomach acid<\/p>\n<\/td><\/tr>

    \n

    Digestion<\/p>\n<\/td>

    		\n

    Th\u00e9rapie enzymatique digestive<\/p>\n<\/td>

    		\n

    Lib\u00e8re des enzymes dans le duod\u00e9num pour la digestion<\/p>\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    Enteric coated pills also come in various forms such as tablets or caplets. Here a table for the comparison for these two forms of enteric coating medicines.<\/p>\n\n\n\n

    \n

    Fonctionnalit\u00e9<\/b><\/strong><\/p>\n<\/td>

    		\n

    Comprim\u00e9s \u00e0 enrobage ent\u00e9rique<\/b><\/strong><\/p>\n<\/td>

    		\n

    Comprim\u00e9s \u00e0 enrobage ent\u00e9rique<\/b><\/strong><\/p>\n<\/td><\/tr>

    \n

    Forme<\/p>\n<\/td>

    		\n

    Rond ou ovale<\/p>\n<\/td>

    		\n

    Oblong, profil\u00e9<\/p>\n<\/td><\/tr>

    \n

    Facilit\u00e9 de d\u00e9glutition<\/p>\n<\/td>

    		\n

    Mod\u00e9r\u00e9<\/p>\n<\/td>

    		\n

    Plus facile que les comprim\u00e9s<\/p>\n<\/td><\/tr>

    \n

    Application de rev\u00eatement<\/p>\n<\/td>

    		\n

    Appliqu\u00e9 via des machines de pelliculage ou de rev\u00eatement en cuve<\/p>\n<\/td>

    		\n

    Identique aux tablettes<\/p>\n<\/td><\/tr>

    \n

    Lieu de dissolution<\/p>\n<\/td>

    		\n

    Intestin (d\u00e9clench\u00e9 par le pH)<\/p>\n<\/td>

    		\n

    Intestin<\/p>\n<\/td><\/tr>

    \n

    Utilisation typique<\/p>\n<\/td>

    		\n

    M\u00e9dicaments sur ordonnance, suppl\u00e9ments<\/p>\n<\/td>

    		\n

    Multivitamines, m\u00e9dicaments en vente libre<\/p>\n<\/td><\/tr>

    \n

    Pr\u00e9f\u00e9rence de fabrication<\/p>\n<\/td>

    		\n

    Rentable, volume \u00e9lev\u00e9<\/p>\n<\/td>

    		\n

    Manipulation facile, moins de poussi\u00e8re<\/p>\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    5. Avantages et inconv\u00e9nients des comprim\u00e9s ent\u00e9riques<\/h2>\n\n\n\n

    Enteric coated tablets are widely used in the pharmaceutical industry for their ability to deliver active ingredients safely and effectively. However, while they provide significant advantages, they also come with certain production and formulation challenges.<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    <\/p>\n\n\n\n

    1) <\/b>Avantages de l'enrobage ent\u00e9rique <\/b><\/strong>Pilules<\/b><\/strong><\/h3>\n\n\n\n